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Rehmannioside D

Animal
Iridoid glycoside

Mechanism of Action

Rehmannioside D demonstrates immunomodulatory activity by promoting T-lymphocyte proliferation, enhancing natural killer cell cytotoxicity, and modulating the Th1/Th2 cytokine balance. It also inhibits HPA axis hyperactivation by modulating corticotropin-releasing hormone (CRH) receptor sensitivity, which underlies the traditional use of Rehmannia for adrenal fatigue and Yin-deficiency heat.
Immune modulation, anti-inflammatory, renal protective effects

Research Notes

Rehmannia (Di Huang)TCM

Animal studies in corticosterone-induced immunosuppressed mice showed that rehmannioside D (20 mg/kg) restored splenic lymphocyte proliferation to near-normal levels (Li et al., Phytomedicine, 2012). In vitro assays demonstrated dose-dependent enhancement of NK cell activity in human peripheral blood mononuclear cells. Clinical data remains limited to observational studies of multi-herb formulas, so the isolated contribution of rehmannioside D is difficult to parse.

Rehmannia Prepared (Shu Di Huang)TCM

Demonstrated immunostimulatory activity in immunosuppressed mice. Protected against cisplatin-induced nephrotoxicity in animal models.

Found In 2 Herbs

Rehmannia (Di Huang)

Rehmannia (Di Huang)

TCM
Rehmannia Prepared (Shu Di Huang)

Rehmannia Prepared (Shu Di Huang)

TCM

3D Molecular Structure

Iridoid glycoside
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Rehmannioside D

Iridoid glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms
Carbon
Oxygen

Related Compounds (Iridoid glycoside)

Acteoside(1)Agnuside(2)Antirrhinoside(1)Aucubin(8)Catalpin (iridoid glycoside)(1)Catalpol(6)Catalpol (iridoid glycoside)(1)Echinacoside(1)Geniposide(1)Lamalbide(1)Ligustroside(1)Monotropein(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.