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Lactucin
AnimalMechanism of Action
Bitter receptor stimulation enhancing digestive secretions; mild sedative-nervine activity
Primary bitter principle responsible for mild sedative, anxiolytic, and analgesic effects; present in leaf latex
Opioid receptor modulation and/or opioid-mimetic action (mechanism not fully clarified); mild analgesic and sedative effects
Research Notes
Chicory RootWestern
Lactucin demonstrates bitter receptor activation comparable to gentian. Animal models show enhanced gastric secretion. Mild anxiolytic properties.
LettuceWestern
Primary bitter principle of Lactuca with documented sedative and anxiolytic activity in animal models.
Wild LettuceWestern
Lactucin is the primary bioactive in wild lettuce with traditional use for mild pain and insomnia spanning centuries in European herbalism. Clinical evidence is limited but observational reports support efficacy for musculoskeletal aches and nerve pain; mechanism possibly involves endogenous opioid system.
Found In 3 Herbs
3D Molecular Structure
Sesquiterpene lactone
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Lactucin
Sesquiterpene lactoneAromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₂₁H₃₀O₂
Atoms
Carbon
Oxygen
Related Compounds (Sesquiterpene lactone)
Live Research
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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.