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Costunolide
In vitro / AnimalMechanism of Action
Selectively alkylates and inhibits IκB kinase (IKK-β), preventing NF-κB nuclear translocation and downstream pro-inflammatory gene expression; inhibits PI3K/Akt and STAT3 signaling pathways; triggers mitochondrial apoptosis via ROS accumulation and cytochrome c release; anti-angiogenic via VEGF receptor downregulation
NF-kB inhibition; anti-inflammatory via iNOS and COX-2 suppression; anti-tumor via apoptosis induction
Research Notes
Bay LeafWestern
In vitro studies show IC50 of 5–20 µM against multiple cancer cell lines including HeLa, HepG2, and MCF-7. NF-κB inhibition validated across at least 12 independent inflammatory models. Limited in vivo data available; anti-cancer activity in animals is promising but clinical evidence is absent.
KushtaAyurvedic
Costunolide is the primary bioactive sesquiterpene lactone in Saussurea costus. Extensive in vitro and animal studies demonstrate potent anti-inflammatory and hepatoprotective effects.
Found In 2 Herbs
3D Molecular Structure
Sesquiterpene lactone
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Costunolide
Sesquiterpene lactoneAromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₂₁H₃₀O₂
Atoms
Carbon
Oxygen
Related Compounds (Sesquiterpene lactone)
Live Research
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