Costunolide

In vitro / Animal

Mechanism of Action

Selectively alkylates and inhibits IκB kinase (IKK-β), preventing NF-κB nuclear translocation and downstream pro-inflammatory gene expression; inhibits PI3K/Akt and STAT3 signaling pathways; triggers mitochondrial apoptosis via ROS accumulation and cytochrome c release; anti-angiogenic via VEGF receptor downregulation

NF-kB inhibition; anti-inflammatory via iNOS and COX-2 suppression; anti-tumor via apoptosis induction

Research Notes

Bay LeafWestern

In vitro studies show IC50 of 5–20 µM against multiple cancer cell lines including HeLa, HepG2, and MCF-7. NF-κB inhibition validated across at least 12 independent inflammatory models. Limited in vivo data available; anti-cancer activity in animals is promising but clinical evidence is absent.

KushtaAyurvedic

Costunolide is the primary bioactive sesquiterpene lactone in Saussurea costus. Extensive in vitro and animal studies demonstrate potent anti-inflammatory and hepatoprotective effects.

Found In 2 Herbs

Bay Leaf

Western

Kushta

Ayurvedic

3D Molecular Structure

Sesquiterpene lactone

Drag to rotate · Click atoms to explore

Costunolide

Sesquiterpene lactoneAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₂₁H₃₀O₂

Atoms

Carbon

Oxygen

Related Compounds (Sesquiterpene lactone)

Absinthin(1)Atractylodide I(1)Bilobalide(1)Cnicin(2)Cnicin-related sesquiterpene lactones(1)Cynaropicrin(1)Dehydrocostus lactone(1)Lactucin(3)Lactucopicrin(2)Taraxacin(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.