Colchicine

Clinical trial

Mechanism of Action

Binds tubulin dimers and prevents polymerisation into microtubules, arresting mitosis at metaphase and halting neutrophil migration into gouty joints; also inhibits NLRP3 inflammasome activation and IL-1β release

Research Notes

Autumn CrocusWestern

First-line pharmaceutical for acute gout and familial Mediterranean fever with strong clinical trial evidence (COPE, COLCOT trials). Mechanism of action well established through decades of clinical and pharmacological research.

Found In 1 Herb

Autumn Crocus

Western

3D Molecular Structure

Alkaloid

Drag to rotate · Click atoms to explore

Colchicine

AlkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Alkaloid)

3-Demethylcolchicine(1)Brahmine(1)Christembine(1)Demecolcine (Colcemid)(1)Fragarine(1)Host-derived alkaloids (variable)(1)Muscarine(1)Punarnavine(1)Pyrrolizidine alkaloids (trace)(1)Sambucine(1)Speciogynine(1)Taspine(1)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.