trans-Anethole

Clinical trial

Mechanism of Action

Bronchial mucus stimulation and antispasmodic via calcium channel antagonism in smooth muscle; phytoestrogenic ER binding (weak agonist); galactagogue via dopamine D2 receptor inhibition elevating prolactin; anti-inflammatory via NF-κB and COX-2 inhibition; antimicrobial through disruption of fungal ergosterol biosynthesis and bacterial lipopolysaccharide membrane integrity.

Estrogen receptor modulation; G-protein coupled receptor 30 activation

Research Notes

AniseWestern

Trans-anethole has established mechanisms for its primary carminative and expectorant activities. European Medicines Agency monograph recognizes evidence for respiratory catarrh and dyspepsia. A Cochrane-adjacent systematic review identified 3 controlled trials supporting antifungal applications. Phytoestrogenic effects confirmed in cell-based assays; galactagogue activity supported by animal studies and ethnobotanical surveys of nursing mothers.

Fennel (Saunf / Xiao Hui Xiang)Western

trans-Anethole exhibits estrogenic activity in vitro through rapid GPR30 signaling and weak classical ER binding. Clinical trials show modest benefit for menopausal vasomotor symptoms with 300-600mg daily.

Found In 2 Herbs

Anise

Western

Fennel (Saunf / Xiao Hui Xiang)

Western

3D Molecular Structure

Phenylpropanoid

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trans-Anethole

PhenylpropanoidBioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Phenylpropanoid)

Apiol(1)Asarone (α and β)(1)beta-Asarone(2)Dill apiole(1)Dillapiole(1)Eugenol(8)Methyleugenol(1)Pseudoisoeugenol II(1)Sparganin(1)α-Asarone(1)β-Asarone(1)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.