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Pseudoisoeugenol II
PreliminaryMechanism of Action
SSRI-like mechanism with in vitro serotonin transporter (SERT) inhibitory activity; antispasmodic through calcium channel antagonism in GI smooth muscle; anti-inflammatory through COX pathway inhibition; distinguishes P. anisum pharmacologically from fennel and star anise which lack this compound.
Research Notes
AniseWestern
In vitro SERT inhibition studies confirm pseudoisoeugenol II has affinity for the serotonin transporter comparable to mild SSRIs. Animal behavioral models show anxiolytic and mild antidepressant activity at oral doses achievable from therapeutic anise preparations. The compound also shows antispasmodic activity in isolated GI tissue preparations. Clinical human data is lacking; evidence primarily preclinical.
Found In 1 Herb
3D Molecular Structure
Phenylpropanoid
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Pseudoisoeugenol II
PhenylpropanoidBioactive phytochemical with therapeutic properties
Representative pattern: C₇H₆O₃
Atoms
Carbon
Oxygen
Hydrogen
Related Compounds (Phenylpropanoid)
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