Pseudoisoeugenol II

Preliminary

Mechanism of Action

SSRI-like mechanism with in vitro serotonin transporter (SERT) inhibitory activity; antispasmodic through calcium channel antagonism in GI smooth muscle; anti-inflammatory through COX pathway inhibition; distinguishes P. anisum pharmacologically from fennel and star anise which lack this compound.

Research Notes

AniseWestern

In vitro SERT inhibition studies confirm pseudoisoeugenol II has affinity for the serotonin transporter comparable to mild SSRIs. Animal behavioral models show anxiolytic and mild antidepressant activity at oral doses achievable from therapeutic anise preparations. The compound also shows antispasmodic activity in isolated GI tissue preparations. Clinical human data is lacking; evidence primarily preclinical.

Found In 1 Herb

Anise

Western

3D Molecular Structure

Phenylpropanoid

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Pseudoisoeugenol II

PhenylpropanoidBioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Phenylpropanoid)

Apiol(1)Asarone (α and β)(1)beta-Asarone(2)Dill apiole(1)Dillapiole(1)Eugenol(8)Methyleugenol(1)Sparganin(1)trans-Anethole(2)α-Asarone(1)β-Asarone(1)

Live Research

Open on PubMed

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