Rhein

Rhein and related anthraquinones in Cassia fistula pulp produce the well-established laxative effect. Clinical use as a mild purgative is supported by pharmacological studies.

Rhein is the primary active metabolite of sennoside hydrolysis. Well-characterised pharmacokinetics and pharmacodynamics in human studies. Also demonstrates antimicrobial and anti-inflammatory properties in vitro.

Rhein is the primary active metabolite responsible for senna's laxative effect. It acts locally on colonic smooth muscle and secretory cells.

Rhein contributes to laxative activity through intestinal secretion and motility stimulation. Antimicrobial activity against gram-positive bacteria documented.