Damnacanthal

Preliminary

Mechanism of Action

Inhibits ras oncogene function by blocking tyrosine kinase phosphorylation, interfering with signal transduction cascades downstream of Ras. Exhibits direct antimicrobial activity via membrane disruption in gram-positive bacteria. Also induces apoptosis in tumor cell lines through activation of caspase-3 and downregulation of Bcl-2 expression.

Research Notes

NoniAyurvedic

In vitro studies by Hiramatsu et al. (1993) identified damnacanthal as a potent inhibitor of ras function, stimulating significant interest in its anticancer potential. Subsequent cell-line studies have confirmed pro-apoptotic activity against lymphoma, breast, and colorectal cancer cells, though in vivo and human clinical data remain absent. Antimicrobial activity has been demonstrated against Staphylococcus aureus and Bacillus subtilis in disk diffusion assays.

Found In 1 Herb

Noni

Ayurvedic

3D Molecular Structure

Anthraquinone

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Damnacanthal

AnthraquinoneBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Related Compounds (Anthraquinone)

Alizarin(2)Anthraquinones (emodin, chrysophanol, physcion)(1)Anthraquinones (emodin, chrysophanol)(1)Chrysophanol(1)Morindone(1)Munjistin(1)Purpurin(2)Rhein(4)Rubiadin(2)

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