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Pleuran (beta-1,3-D-glucan)

Clinical trial
Polysaccharide (beta-glucan)

Mechanism of Action

Pleuran is a (1->3)-beta-D-glucan that activates innate immune responses by binding to dectin-1, complement receptor 3 (CR3), and Toll-like receptor 2 (TLR2) on macrophages, dendritic cells, and neutrophils. This triggers downstream signaling through NF-kB and MAPK pathways, stimulating production of pro-inflammatory cytokines including TNF-alpha, IL-1beta, IL-6, and IL-12. Pleuran potentiates the Th1 immune phenotype through the macrophage-IL-12-IFN-gamma axis and enhances natural killer (NK) cell cytotoxicity against tumor cells.

Research Notes

Oyster MushroomMushroom

A randomized, double-blind, placebo-controlled trial demonstrated that pleuran supplementation significantly reduced upper respiratory tract infection incidence and increased circulating NK cell counts in athletes. A pediatric RCT showed pleuran reduced peripheral blood eosinophilia and stabilized serum IgE levels in children with recurrent respiratory infections. In animal models, a diet containing 10% pleuran significantly inhibited the development of aberrant crypt foci, a precancerous marker in colon tissue.

Found In 1 Herb

Oyster Mushroom

Oyster Mushroom

Mushroom

3D Molecular Structure

Polysaccharide (beta-glucan)
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Pleuran (beta-1,3-D-glucan)

Polysaccharide (beta-glucan)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms
Carbon
Oxygen

Related Compounds (Polysaccharide (beta-glucan))

(1→3)(1→6)-Beta-D-Glucan (High Molecular Weight)(1)Beta-1,3/1,6-Glucans(1)Beta-glucan polysaccharides (GAP fractions)(1)

Live Research

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This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.