Beta-1,3/1,6-Glucans

Beta-glucans from Agarikon are recognized by pattern recognition receptors on innate immune cells: Dectin-1, complement receptor type 3 (CR3), and TLR-2/6 on macrophages, neutrophils, monocytes, natural killer cells, and dendritic cells. Receptor binding triggers activation of both innate and acquired immunity pathways, including TNF-α and interferon production, complement system activation, and enhanced antitumor immunity through NK cell cytotoxicity. The combination of water-soluble beta-glucans with lipophilic triterpenoids and chlorinated coumarins creates multi-pathway immune activation unique to Agarikon.