Beta-glucan polysaccharides (GAP fractions)

Preliminary

Mechanism of Action

Unique polysaccharide composition with glucose:mannose:galactose:glucuronic acid:xylose ratio of 82.0:5.6:4.3:4.2:3.9 and molecular weights ranging from 19.5 kDa to 107 kDa. Higher molecular weight fractions show superior immunomodulatory activity, stimulating macrophage and dendritic cell activation via Dectin-1 and TLR pathways. Trigger secretion of TNF-alpha, IFN-gamma, and IL-1-beta, enhance NK cell cytotoxicity (51.6% increase at optimal dosing), and stimulate T and B cell proliferation.

Research Notes

Artist's ConkMushroom

Exo-biopolymer (EXP) from G. applanatum administered intraperitoneally at 40 mg/kg body weight reduced tumor formation by 39.7% versus control in sarcoma-180-bearing mice, with concurrent 51.6% increase in NK cell activity. DPPH radical scavenging reached 94.83% at 2.0 mg/mL for methanol extract, comparable to BHT standard. Polysaccharide fractions (GAP-40, GAP-60, GAP-80) showed dose-dependent antioxidant and immunostimulatory activity in preclinical models.

Found In 1 Herb

Artist's Conk

Mushroom

3D Molecular Structure

Polysaccharide (beta-glucan)

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Beta-glucan polysaccharides (GAP fractions)

Polysaccharide (beta-glucan)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms

Carbon

Oxygen

Related Compounds (Polysaccharide (beta-glucan))

(1→3)(1→6)-Beta-D-Glucan (High Molecular Weight)(1)Beta-1,3/1,6-Glucans(1)Pleuran (beta-1,3-D-glucan)(1)

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