AlertsSign in
Back to Compound Explorer

Hispidulin

In vitro / Animal
Flavone

Mechanism of Action

Inhibits aldose reductase enzyme (involved in diabetic complications via the polyol pathway). Acts as a partial agonist at GABA-A receptors with anxiolytic-like activity. Also demonstrates anti-inflammatory effects through inhibition of 5-LOX and COX-2.
Anti-inflammatory and anti-febrile flavone with confirmed hepatoprotective and neuroprotective activity in preclinical research

Research Notes

CarquejaSouth American

In vitro assays demonstrated that hispidulin from B. trimera inhibited aldose reductase with IC50 of approximately 1.3 μM, suggesting potential for prevention of diabetic complications. Animal studies confirmed anxiolytic-like effects in the elevated plus-maze model. Anti-inflammatory activity was demonstrated in multiple in vitro inflammation assays.

Star ThistleWestern

Hispidulin demonstrates hepatoprotective and neuroprotective activity in preclinical models. Anti-inflammatory and anti-febrile properties established.

Found In 2 Herbs

Carqueja

Carqueja

South American
Star Thistle

Star Thistle

Western

3D Molecular Structure

Flavone
Drag to rotate · Click atoms to explore

Hispidulin

FlavoneBioactive phytochemical with therapeutic properties

Representative pattern: C₁₅H₁₀O₃

Atoms
Carbon
Oxygen

Related Compounds (Flavone)

Chrysin(1)Flavonoids (luteolin, apigenin)(1)Jaceosidin(1)Luteolin(14)Tricin(3)Wogonin(2)

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.