Erythravine

Animal

Mechanism of Action

Modulates GABAergic neurotransmission through positive allosteric modulation of GABA-A receptors, particularly at the benzodiazepine binding site. Also interacts with serotonergic 5-HT1A receptors, producing combined anxiolytic and mildly sedative effects.

Research Notes

MulunguSouth American

A 2006 study in the Journal of Pharmacy and Pharmacology demonstrated that erythravine produced anxiolytic effects in the elevated plus-maze test in mice at doses comparable to diazepam (1 mg/kg), without significant sedation at therapeutic doses. A follow-up study confirmed that the anxiolytic effect was blocked by flumazenil, indicating GABAergic mediation.

Found In 1 Herb

Mulungu

South American

3D Molecular Structure

Erythrinan alkaloid

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Erythravine

Erythrinan alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Erythrinan alkaloid)

Erysodine(1)Erythrinine(1)

Live Research

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