Erysodine

In vitro

Mechanism of Action

Competitive antagonist at alpha-4-beta-2 nicotinic acetylcholine receptors (nAChRs), the primary subtype mediating nicotine addiction. Blocks nicotine binding without producing significant agonist activity.

Research Notes

MulunguSouth American

Erysodine has been characterized as a potent and selective alpha-4-beta-2 nAChR antagonist with Ki values of approximately 10 nM in radioligand binding assays. Studies published in Molecular Pharmacology demonstrated its selectivity over other nAChR subtypes. This has led to interest in Erythrina alkaloids as potential templates for smoking cessation therapeutics.

Found In 1 Herb

Mulungu

South American

3D Molecular Structure

Erythrinan alkaloid

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Erysodine

Erythrinan alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Erythrinan alkaloid)

Erythravine(1)Erythrinine(1)

Live Research

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