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Uzarin

Established
Cardenolide cardiac glycoside

Mechanism of Action

Partial inhibitor of Na⁺/K⁺-ATPase in intestinal smooth muscle cells, reducing peristaltic motility and fluid secretion into the intestinal lumen; electrolyte reabsorption is promoted. Cardiac Na⁺/K⁺-ATPase inhibition is minimal at therapeutic doses due to lower binding affinity compared to digoxin, but escalates significantly in overdose.
Partial inhibitor of Na⁺/K⁺-ATPase in intestinal smooth muscle cells, reducing peristaltic motility and fluid secretion into the intestinal lumen; electrolyte reabsorption is promoted without significant cardiac Na⁺/K⁺-ATPase inhibition at therapeutic doses.

Research Notes

UzaraAfrican

Clinical studies supporting Uzara® approval in Germany demonstrate reduction in stool frequency and duration of acute non-specific diarrhoea comparable to loperamide in mild to moderate cases. Cardiac effects at therapeutic doses are minimal but increase significantly with overdose or concurrent digitalis use. Commission E positive monograph issued 1987.

UzaraAfrican

Clinical studies supporting Uzara® approval in Germany show reduction in stool frequency and duration of acute diarrhoea comparable to loperamide in mild to moderate cases. Cardiac effects at therapeutic doses are minimal but increase significantly in overdose or concurrent digitalis use.

Found In 2 Herbs

Uzara

Uzara

African
Uzara

Uzara

African

3D Molecular Structure

Cardenolide cardiac glycoside
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Uzarin

Cardenolide cardiac glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms
Carbon
Oxygen

Related Compounds (Cardenolide cardiac glycoside)

Xysmalobin(2)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.