Unsaturated pyrrolizidine alkaloids (trace)

Case report

Mechanism of Action

Hepatotoxic through pyrrolic metabolite formation via CYP3A4; pyrrolic metabolites alkylate hepatocyte DNA and proteins causing veno-occlusive disease at high or chronic doses

Research Notes

Gravel RootWestern

Eutrochium purpureum contains trace levels of pyrrolizidine alkaloids, though at significantly lower concentrations than high-risk PA plants (Senecio, Symphytum). The specific PA profile of gravel root is not fully characterized. Risk assessment suggests short-term use at recommended doses poses minimal risk, but long-term use should be avoided as a precaution.

Found In 1 Herb

Gravel Root

Western

3D Molecular Structure

Pyrrolizidine alkaloid

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Unsaturated pyrrolizidine alkaloids (trace)

Pyrrolizidine alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Pyrrolizidine alkaloid)

Heliosupine(1)

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