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Unsaturated pyrrolizidine alkaloids (trace)
Case reportMechanism of Action
Hepatotoxic through pyrrolic metabolite formation via CYP3A4; pyrrolic metabolites alkylate hepatocyte DNA and proteins causing veno-occlusive disease at high or chronic doses
Research Notes
Gravel RootWestern
Eutrochium purpureum contains trace levels of pyrrolizidine alkaloids, though at significantly lower concentrations than high-risk PA plants (Senecio, Symphytum). The specific PA profile of gravel root is not fully characterized. Risk assessment suggests short-term use at recommended doses poses minimal risk, but long-term use should be avoided as a precaution.
Found In 1 Herb
3D Molecular Structure
Pyrrolizidine alkaloid
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Unsaturated pyrrolizidine alkaloids (trace)
Pyrrolizidine alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Pyrrolizidine alkaloid)
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