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Heliosupine
Clinical trialMechanism of Action
Metabolised in the liver to reactive pyrrole intermediates that cross-link DNA and proteins, causing hepatocyte necrosis and veno-occlusive disease
Research Notes
Hound's TongueWestern
Pyrrolizidine alkaloid hepatotoxicity is well-established. Cumulative effect detectable only by liver biopsy. Numerous case reports of hepatic veno-occlusive disease from PA-containing plants.
Found In 1 Herb
3D Molecular Structure
Pyrrolizidine alkaloid
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Heliosupine
Pyrrolizidine alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Pyrrolizidine alkaloid)
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