Thujone

In vitro / Animal

Mechanism of Action

GABA-A receptor antagonist (blocks chloride channel); convulsant at high doses; insecticidal

GABA-A receptor antagonist; antiparasitic through disruption of parasite neuromuscular function

Research Notes

Well-established GABA-A antagonism; toxic at high doses; convulsant in animal models; present in absinthe (wormwood) at higher levels

WormwoodWestern

Thujone has antiparasitic activity against intestinal helminths. However, it is also neurotoxic at high doses, antagonising GABA receptors and potentially causing seizures. This necessitates careful dosing and short-term use.

Found In 2 Herbs

Mugwort

Western

Wormwood

Western

3D Molecular Structure

Monoterpene ketone (bicyclic)

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Thujone

Monoterpene ketone (bicyclic)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Monoterpene ketone (bicyclic))

Alpha-thujone(1)

Live Research

Open on PubMed

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