Alpha-thujone

Preliminary

Mechanism of Action

Alpha-thujone acts as a GABA-A receptor antagonist at the picrotoxin binding site, reducing chloride ion conductance and increasing neuronal excitability. At low doses, this produces mild cognitive stimulation and enhanced alertness. It also demonstrates antimicrobial activity against gram-positive bacteria and several fungal species through disruption of cell membrane integrity.

Research Notes

White SageWestern

Thujone content in white sage is variable (2–15% of essential oil) and contributes to both its bioactivity and its toxicity profile. The European Medicines Agency limits thujone in herbal preparations to a maximum daily intake of 6 mg. Animal studies demonstrate convulsant activity at doses far exceeding those achieved through normal herbal use. Antimicrobial studies confirm activity against S. aureus and C. albicans at concentrations achievable in topical preparations.

Found In 1 Herb

White Sage

Western

3D Molecular Structure

Monoterpene ketone (bicyclic)

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Alpha-thujone

Monoterpene ketone (bicyclic)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Monoterpene ketone (bicyclic))

Thujone(2)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.