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Sanguinarine
In vitroMechanism of Action
Intercalates DNA and inhibits topoisomerase; disrupts microbial cell membranes through interaction with membrane-bound enzymes; inhibits NF-kB signaling; induces apoptosis in cancer cell lines via mitochondrial pathway; at high concentrations causes direct tissue necrosis through protein denaturation
Antimicrobial through topoisomerase inhibition and cell membrane disruption; anti-inflammatory via TNF-alpha suppression
Research Notes
BloodrootWestern
Sanguinarine has demonstrated potent antimicrobial activity against Staphylococcus aureus (including MRSA), Streptococcus mutans, Candida albicans, and other pathogens in vitro. Anti-tumor activity has been shown in multiple cancer cell lines. Former use in dental products (Viadent toothpaste) was discontinued due to association with oral leukoplakia in long-term users. Cytotoxic concentration range is narrow, limiting therapeutic applications.
Chelidonium (Celandine)Western
Sanguinarine demonstrates antimicrobial activity against oral and GI pathogens. Anti-inflammatory effects documented in LPS-induced inflammation models.
Found In 2 Herbs
3D Molecular Structure
Benzophenanthridine isoquinoline alkaloid
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Sanguinarine
Benzophenanthridine isoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Benzophenanthridine isoquinoline alkaloid)
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