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Sanguinarine

In vitro
Benzophenanthridine isoquinoline alkaloid

Mechanism of Action

Intercalates DNA and inhibits topoisomerase; disrupts microbial cell membranes through interaction with membrane-bound enzymes; inhibits NF-kB signaling; induces apoptosis in cancer cell lines via mitochondrial pathway; at high concentrations causes direct tissue necrosis through protein denaturation
Antimicrobial through topoisomerase inhibition and cell membrane disruption; anti-inflammatory via TNF-alpha suppression

Research Notes

BloodrootWestern

Sanguinarine has demonstrated potent antimicrobial activity against Staphylococcus aureus (including MRSA), Streptococcus mutans, Candida albicans, and other pathogens in vitro. Anti-tumor activity has been shown in multiple cancer cell lines. Former use in dental products (Viadent toothpaste) was discontinued due to association with oral leukoplakia in long-term users. Cytotoxic concentration range is narrow, limiting therapeutic applications.

Chelidonium (Celandine)Western

Sanguinarine demonstrates antimicrobial activity against oral and GI pathogens. Anti-inflammatory effects documented in LPS-induced inflammation models.

Found In 2 Herbs

Bloodroot

Bloodroot

Western
Chelidonium (Celandine)

Chelidonium (Celandine)

Western

3D Molecular Structure

Benzophenanthridine isoquinoline alkaloid
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Sanguinarine

Benzophenanthridine isoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms
Nitrogen
Carbon
Hydrogen
Oxygen

Related Compounds (Benzophenanthridine isoquinoline alkaloid)

Chelerythrine(1)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.