Chelerythrine

In vitro

Benzophenanthridine isoquinoline alkaloid

Mechanism of Action

Potent and selective inhibitor of protein kinase C (PKC); antimicrobial through similar mechanisms to sanguinarine; induces apoptosis preferentially in rapidly dividing cells; anti-inflammatory through suppression of TNF-alpha and IL-1beta

Research Notes

BloodrootWestern

Chelerythrine is one of the most studied natural PKC inhibitors and has been used as a research tool in cell biology. Its antimicrobial and anti-inflammatory activities complement those of sanguinarine. PKC inhibition has implications for anti-cancer research, but clinical applications are limited by toxicity. Selectivity for PKC isoforms varies.

Found In 1 Herb

Bloodroot

Western

3D Molecular Structure

Benzophenanthridine isoquinoline alkaloid

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Chelerythrine

Benzophenanthridine isoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Benzophenanthridine isoquinoline alkaloid)

Sanguinarine(2)

Live Research

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