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Chelerythrine
In vitroMechanism of Action
Potent and selective inhibitor of protein kinase C (PKC); antimicrobial through similar mechanisms to sanguinarine; induces apoptosis preferentially in rapidly dividing cells; anti-inflammatory through suppression of TNF-alpha and IL-1beta
Research Notes
BloodrootWestern
Chelerythrine is one of the most studied natural PKC inhibitors and has been used as a research tool in cell biology. Its antimicrobial and anti-inflammatory activities complement those of sanguinarine. PKC inhibition has implications for anti-cancer research, but clinical applications are limited by toxicity. Selectivity for PKC isoforms varies.
Found In 1 Herb
3D Molecular Structure
Benzophenanthridine isoquinoline alkaloid
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Chelerythrine
Benzophenanthridine isoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Benzophenanthridine isoquinoline alkaloid)
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