Rutin (Quercetin-3-O-rutinoside)

Rutin demonstrates consistent anti-inflammatory and vascular-protective effects across multiple in vitro and animal studies. Clinical data for rutin alone limited; pharmacokinetic studies confirm systemic absorption following oral administration. Capillary fragility reduction documented in clinical studies. Antioxidant activity confirmed in human supplementation studies.

Clinical trials on rutin are most robust for venous insufficiency and capillary fragility: a double-blind RCT (n=40) found 500 mg rutin twice daily significantly reduced capillary fragility and lower limb edema over 6 weeks versus placebo. Animal studies confirm rutin's antidiabetic activity: 100 mg/kg/day reduced HbA1c by 1.8% and improved kidney function markers in streptozotocin diabetic rats over 30 days. Meta-analyses of dietary flavonoid intake (including rutin-containing foods) associate higher intake with 12–18% reduction in cardiovascular event risk in observational cohorts. Tarragon-specific rutin content and its clinical contribution to the herb's antidiabetic profile have not been isolated in clinical trials.