Kaempferol-3-O-rutinoside (Nicotiflorin)

Preliminary

Mechanism of Action

Inhibits adenosine deaminase, raising local adenosine levels — a neuromodulator with anxiolytic and sedative properties through A1 receptor activation. Vasodilatory effects through endothelial nitric oxide synthase (eNOS) activation and direct smooth muscle calcium channel antagonism. Inhibits platelet aggregation and thromboxane B2 synthesis. Antioxidant via direct radical scavenging and chelation of pro-oxidant metals.

Research Notes

Linden / Lime BlossomWestern

Adenosine deaminase inhibition by kaempferol glycosides provides a plausible neurochemical mechanism for linden's traditional nervine and hypotensive uses distinct from direct GABAergic activity. Vascular relaxation studies in isolated aortic rings demonstrate direct vasorelaxant effects at physiologically relevant concentrations. Human pharmacokinetic data shows moderate bioavailability of kaempferol aglycone after deglycosylation by intestinal and colonic microbiota enzymes.

Found In 1 Herb

Linden / Lime Blossom

Western

3D Molecular Structure

Flavonol glycoside

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Kaempferol-3-O-rutinoside (Nicotiflorin)

Flavonol glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Related Compounds (Flavonol glycoside)

Rutin (Quercetin-3-O-rutinoside)(2)

Live Research

Open on PubMed

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