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Kaempferol-3-O-rutinoside (Nicotiflorin)
PreliminaryMechanism of Action
Inhibits adenosine deaminase, raising local adenosine levels — a neuromodulator with anxiolytic and sedative properties through A1 receptor activation. Vasodilatory effects through endothelial nitric oxide synthase (eNOS) activation and direct smooth muscle calcium channel antagonism. Inhibits platelet aggregation and thromboxane B2 synthesis. Antioxidant via direct radical scavenging and chelation of pro-oxidant metals.
Research Notes
Linden / Lime BlossomWestern
Adenosine deaminase inhibition by kaempferol glycosides provides a plausible neurochemical mechanism for linden's traditional nervine and hypotensive uses distinct from direct GABAergic activity. Vascular relaxation studies in isolated aortic rings demonstrate direct vasorelaxant effects at physiologically relevant concentrations. Human pharmacokinetic data shows moderate bioavailability of kaempferol aglycone after deglycosylation by intestinal and colonic microbiota enzymes.
Found In 1 Herb
3D Molecular Structure
Flavonol glycoside
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Kaempferol-3-O-rutinoside (Nicotiflorin)
Flavonol glycosideSugar-bound molecules that control drug release in the body
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
Related Compounds (Flavonol glycoside)
Live Research
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