Polyporenic Acid C

In vitro

Mechanism of Action

Polyporenic acid C and related 24-methylene lanostane triterpenoids from F. betulina exhibit dual anti-inflammatory and antimicrobial activity. Anti-inflammatory effects are mediated through inhibition of 3-alpha-hydroxysteroid dehydrogenase (3-alpha-HSD) and through inhibition of bacterial hyaluronate lyase. Additionally, polyporenic acids suppress COX-2-mediated prostaglandin synthesis and reduce pro-inflammatory cytokine production (TNF-alpha, IL-6, IL-1beta) in activated macrophage models.

Research Notes

Birch PolyporeMushroom

A comprehensive phytochemical investigation identified 47 distinct lanostane-type triterpenoids in F. betulina, including 13 previously unreported structures designated polyporenic acids E through M. Polyporenic acid C demonstrated the strongest anti-inflammatory activity in the series, with potent inhibition of 3-alpha-HSD and bacterial hyaluronate lyase in enzyme inhibition assays. Cytotoxicity screening revealed moderate antiproliferative activity against several cancer cell lines. Trypanocidal activity was also documented against Trypanosoma brucei.

Found In 1 Herb

Birch Polypore

Mushroom

3D Molecular Structure

Lanostane-type triterpenoid

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Polyporenic Acid C

Lanostane-type triterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Lanostane-type triterpenoid)

Ganodermanontriol(1)

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