Ganodermanontriol

Preliminary

Mechanism of Action

Ganodermanontriol is a cytotoxic triterpenoid that inhibits cancer cell proliferation and invasiveness through suppression of the AP-1 transcription factor and downstream matrix metalloproteinases (MMP-2, MMP-9), which are critical for tumor metastasis. It also inhibits CDC20 expression, disrupting mitotic progression in cancer cells. Additionally, it demonstrates strong antioxidant activity through lipid peroxidation inhibition and free radical scavenging.

Research Notes

ReishiMushroom

Ganodermanontriol was shown to inhibit highly invasive breast cancer cell growth and invasion at 5–20 µg/mL in vitro by suppressing AP-1 and MMP secretion (Jiang et al., 2004, International Journal of Cancer). Animal studies in MDA-MB-231 xenograft models demonstrated reduced tumor volume and metastatic spread. All research to date is preclinical (in vitro and animal models). Found primarily in the fruiting body; extraction requires ethanol or ethyl acetate solvent systems.

Found In 1 Herb

Reishi

Mushroom

3D Molecular Structure

Lanostane-type triterpenoid

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Ganodermanontriol

Lanostane-type triterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Lanostane-type triterpenoid)

Polyporenic Acid C(1)

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.