Nothofagin

In vitro

Mechanism of Action

Scavenges superoxide and hydroxyl radicals, inhibits lipid peroxidation, and suppresses pro-inflammatory cytokine production (TNF-α, IL-6). Structurally related to aspalathin and thought to act synergistically with it.

Exhibits antioxidant and anti-inflammatory activity through free radical scavenging and inhibition of pro-inflammatory cytokine production; structurally related to aspalathin and co-occurs uniquely in rooibos.

Research Notes

RooibosAfrican

In vitro evidence demonstrates cytoprotective and anti-inflammatory activity. Its contribution in vivo is considered supplementary to aspalathin; no standalone human clinical trials exist as of 2025.

RooibosAfrican

In vitro studies show nothofagin reduces oxidative stress markers and inhibits lipid peroxidation. It is thought to act synergistically with aspalathin, contributing to rooibos's overall cytoprotective profile.

Found In 2 Herbs

Rooibos

African

Rooibos

African

3D Molecular Structure

Dihydrochalcone flavonoid

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Nothofagin

Dihydrochalcone flavonoidPolyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Related Compounds (Dihydrochalcone flavonoid)

Aspalathin(2)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.