Aspalathin

In vitro / Animal

Mechanism of Action

Activates AMPK signalling, promotes GLUT4-mediated glucose uptake in skeletal muscle, inhibits NF-κB-driven inflammatory gene expression, and scavenges reactive oxygen species directly. Unique to Aspalathus linearis.

Activates AMPK signalling, inhibits NF-κB-mediated inflammatory pathways, and exhibits antioxidant activity via direct radical scavenging; unique to Aspalathus linearis. Also modulates glucose uptake in skeletal muscle cells via GLUT4 translocation.

Research Notes

RooibosAfrican

Preclinical studies in diabetic rodent models show significant reductions in fasting blood glucose and improved insulin sensitivity. Human pharmacokinetic data confirm oral bioavailability and rapid plasma peak within 1 hour; clinical intervention trials on glycaemic outcomes remain limited but are ongoing.

RooibosAfrican

Preclinical studies demonstrate significant antidiabetic and cardioprotective effects, including reduced fasting blood glucose and improved insulin sensitivity in murine models. Human clinical data remain limited, but aspalathin is considered the primary bioactive responsible for rooibos's metabolic benefits.

Found In 2 Herbs

Rooibos

African

Rooibos

African

3D Molecular Structure

Dihydrochalcone flavonoid

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Aspalathin

Dihydrochalcone flavonoidPolyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Related Compounds (Dihydrochalcone flavonoid)

Nothofagin(2)

Live Research

Open on PubMed

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.