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Isoalchorneine
In vitro / AnimalMechanism of Action
Contributes to anti-inflammatory activity through inhibition of 5-lipoxygenase (5-LOX) pathway, reducing leukotriene synthesis. May also modulate TNF-alpha and IL-1beta expression in activated macrophages.
Research Notes
IporuruSouth American
In vitro studies on lipopolysaccharide-stimulated macrophages showed dose-dependent suppression of pro-inflammatory cytokines by A. castaneifolia bark extract, with isoalchorneine identified as a contributing active compound. Animal models of carrageenan-induced paw edema demonstrated significant anti-inflammatory effects.
Found In 1 Herb
3D Molecular Structure
Guanidine alkaloid
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Isoalchorneine
Guanidine alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Guanidine alkaloid)
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