Alchorneine

Animal

Mechanism of Action

Binds to opioid receptors (particularly mu and delta subtypes), producing analgesic effects. Also inhibits prostaglandin synthesis through COX-2 suppression, contributing to both analgesic and anti-inflammatory activity.

Research Notes

IporuruSouth American

In vitro receptor binding assays demonstrated alchorneine's affinity for mu-opioid receptors with Ki values in the low micromolar range. Animal studies (hot-plate and writhing tests in mice) showed significant dose-dependent analgesic effects comparable to moderate doses of standard analgesics. A 2003 study in the Journal of Ethnopharmacology confirmed anti-nociceptive activity of the bark extract in multiple pain models.

Found In 1 Herb

Iporuru

South American

3D Molecular Structure

Guanidine alkaloid

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Alchorneine

Guanidine alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Guanidine alkaloid)

Isoalchorneine(1)

Live Research

Open on PubMed

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