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Alchorneine
AnimalMechanism of Action
Binds to opioid receptors (particularly mu and delta subtypes), producing analgesic effects. Also inhibits prostaglandin synthesis through COX-2 suppression, contributing to both analgesic and anti-inflammatory activity.
Research Notes
IporuruSouth American
In vitro receptor binding assays demonstrated alchorneine's affinity for mu-opioid receptors with Ki values in the low micromolar range. Animal studies (hot-plate and writhing tests in mice) showed significant dose-dependent analgesic effects comparable to moderate doses of standard analgesics. A 2003 study in the Journal of Ethnopharmacology confirmed anti-nociceptive activity of the bark extract in multiple pain models.
Found In 1 Herb
3D Molecular Structure
Guanidine alkaloid
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Alchorneine
Guanidine alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Guanidine alkaloid)
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