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Hayatine
In vitroMechanism of Action
Acts as a smooth muscle relaxant through non-competitive antagonism of calcium channels in uterine and vascular smooth muscle cells. Reduces intracellular calcium influx, thereby inhibiting muscle contraction. Also exhibits weak nicotinic receptor antagonism related to its structural similarity to d-tubocurarine.
Research Notes
AbutaSouth American
In vitro studies on isolated uterine smooth muscle preparations demonstrated significant dose-dependent relaxation by hayatine, confirming the traditional use for menstrual cramps and uterine spasm. Receptor binding studies showed moderate affinity for nicotinic acetylcholine receptors (Ki ~1–10 μM), but significantly less than d-tubocurarine, explaining the traditional safety at recommended doses.
Found In 1 Herb
3D Molecular Structure
Bisbenzylisoquinoline alkaloid
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Hayatine
Bisbenzylisoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects
Representative pattern: C₉H₇N₂O
Atoms
Nitrogen
Carbon
Hydrogen
Oxygen
Related Compounds (Bisbenzylisoquinoline alkaloid)
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