Hayatine

In vitro

Mechanism of Action

Acts as a smooth muscle relaxant through non-competitive antagonism of calcium channels in uterine and vascular smooth muscle cells. Reduces intracellular calcium influx, thereby inhibiting muscle contraction. Also exhibits weak nicotinic receptor antagonism related to its structural similarity to d-tubocurarine.

Research Notes

AbutaSouth American

In vitro studies on isolated uterine smooth muscle preparations demonstrated significant dose-dependent relaxation by hayatine, confirming the traditional use for menstrual cramps and uterine spasm. Receptor binding studies showed moderate affinity for nicotinic acetylcholine receptors (Ki ~1–10 μM), but significantly less than d-tubocurarine, explaining the traditional safety at recommended doses.

Found In 1 Herb

Abuta

South American

3D Molecular Structure

Bisbenzylisoquinoline alkaloid

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Hayatine

Bisbenzylisoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Bisbenzylisoquinoline alkaloid)

Berbamine(2)Cissampeline(1)Thalictrine(1)

Live Research

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