Cissampeline

In vitro

Mechanism of Action

Demonstrates antimalarial activity through inhibition of Plasmodium falciparum growth by disrupting parasite hemoglobin degradation in the food vacuole. Also shows anti-inflammatory activity via inhibition of TNF-alpha release from activated macrophages.

Research Notes

AbutaSouth American

In vitro studies demonstrated activity against chloroquine-resistant P. falciparum strains with IC50 values of 0.5–2 μM. A 2010 study in the Journal of Ethnopharmacology confirmed the antimalarial activity of the total alkaloid fraction and identified cissampeline as a major active component. Anti-inflammatory studies showed significant inhibition of TNF-alpha and IL-6 in LPS-stimulated human monocytes.

Found In 1 Herb

Abuta

South American

3D Molecular Structure

Bisbenzylisoquinoline alkaloid

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Cissampeline

Bisbenzylisoquinoline alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Related Compounds (Bisbenzylisoquinoline alkaloid)

Berbamine(2)Hayatine(1)Thalictrine(1)

Live Research

Open on PubMed

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