Dictyophorine A

Preliminary

Mechanism of Action

Stimulates nerve growth factor (NGF) synthesis and secretion from astroglial cells. Dictyophorine A enhanced NGF synthesis approximately four-fold in treated rat astroglial cells, promoting neuronal differentiation and survival through TrkA receptor-mediated signaling cascades including the MAPK/ERK and PI3K/Akt pathways.

Research Notes

Bamboo FungusMushroom

Isolated and characterized by Kawagishi et al. (1997) from Dictyophora indusiata fruiting bodies. In vitro studies using rat astroglial cell cultures demonstrated significant dose-dependent NGF-inducing activity. The compound represents a rare non-polysaccharide neuroactive metabolite from an edible mushroom. Further neurotrophic studies remain at the in vitro stage.

Found In 1 Herb

Bamboo Fungus

Mushroom

3D Molecular Structure

Eudesmane-type sesquiterpene

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Dictyophorine A

Eudesmane-type sesquiterpeneAromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Related Compounds (Eudesmane-type sesquiterpene)

Dictyophorine B(1)

Live Research

Open on PubMed

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