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Dictyophorine A
PreliminaryMechanism of Action
Stimulates nerve growth factor (NGF) synthesis and secretion from astroglial cells. Dictyophorine A enhanced NGF synthesis approximately four-fold in treated rat astroglial cells, promoting neuronal differentiation and survival through TrkA receptor-mediated signaling cascades including the MAPK/ERK and PI3K/Akt pathways.
Research Notes
Bamboo FungusMushroom
Isolated and characterized by Kawagishi et al. (1997) from Dictyophora indusiata fruiting bodies. In vitro studies using rat astroglial cell cultures demonstrated significant dose-dependent NGF-inducing activity. The compound represents a rare non-polysaccharide neuroactive metabolite from an edible mushroom. Further neurotrophic studies remain at the in vitro stage.
Found In 1 Herb
3D Molecular Structure
Eudesmane-type sesquiterpene
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Dictyophorine A
Eudesmane-type sesquiterpeneAromatic plant metabolites with anti-inflammatory properties
Representative pattern: C₁₀H₁₆O
Atoms
Carbon
Oxygen
Hydrogen
Related Compounds (Eudesmane-type sesquiterpene)
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