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How we compile, grade, and present herb-drug interaction data — and its limitations.
The herb-drug interaction information provided by HerbOS is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. This database is not a substitute for professional medical consultation.
Always consult a qualified healthcare provider — including your prescribing physician and pharmacist — before combining herbal supplements with prescription medications or making changes to your medication regimen.
Professional tier content is intended exclusively for licensed healthcare professionals. Clinical management guidance represents synthesized, literature-based recommendations and does not replace individualized clinical judgment. Healthcare professionals should verify all information against current peer-reviewed literature before applying it to patient care.
Our interaction database draws from the following primary sources:
Each interaction is assigned an evidence level reflecting the strength and type of available evidence, from strongest to weakest:
Systematic pooling of data from multiple clinical trials. Highest level of evidence.
Comprehensive synthesis of existing research using defined methodology.
Controlled human studies — pharmacokinetic studies or randomized trials.
Cohort or cross-sectional studies in humans, without randomization.
Published individual case reports or series documenting the interaction.
Evidence from animal models only; extrapolation to humans is uncertain.
Laboratory studies only; clinical relevance at physiological concentrations is uncertain.
Separate from evidence level, we assign a clinical significance rating:
Users of this database should be aware of the following inherent limitations:
Always seek urgent medical advice if you experience:
For questions about your specific medications and supplements, consult your pharmacist — they have access to your complete medication list and specialized drug interaction expertise.
If you believe any interaction data in our database is inaccurate, incomplete, or outdated, please contact our clinical review team. We take data quality seriously and review all submissions.
clinical@herbos.appPlease include: the herb name, drug name, the specific field in question, and the supporting reference (PMID if available).