Zhankuic Acid A

In vitro / Animal

Mechanism of Action

Zhankuic acids are ergostane-type triterpenoids with potent cytotoxic and anti-inflammatory activity. Zhankuic acid A inhibits the NF-kB signaling pathway by preventing IkBa degradation and subsequent p65 nuclear translocation, thereby suppressing transcription of pro-inflammatory mediators including iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6. It also induces apoptosis in cancer cells through activation of the intrinsic mitochondrial pathway, involving cytochrome c release, caspase-9 and caspase-3 activation, and PARP cleavage. Anti-hepatotoxic effects are mediated through upregulation of antioxidant enzymes (SOD, catalase, GPx) and suppression of lipid peroxidation.

Research Notes

Antrodia / Niu Zhang ZhiMushroom

Zhankuic acids A, B, and C were among the first unique triterpenoids identified from Antrodia and remain signature compounds used for chemotaxonomic identification. In vitro studies demonstrated significant cytotoxicity against human liver cancer, lung cancer, and leukemia cell lines with IC50 values in the low micromolar range. Animal studies using CCl4-induced hepatotoxicity models showed that zhankuic acid-containing extracts reduced serum ALT and AST levels and preserved hepatocyte architecture. The compounds are primarily found in wild fruiting bodies and wood-cultured specimens, with lower concentrations in submerged fermentation products.

Found In 1 Herb

Antrodia / Niu Zhang Zhi

Mushroom

3D Molecular Structure

Ergostane-type triterpenoid

Drag to rotate · Click atoms to explore

Zhankuic Acid A

Ergostane-type triterpenoidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare practitioner before using any herbal product.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This content is for educational purposes only and is not a substitute for professional medical advice.