Xanthones (Garcinia-type)

In vitro

Mechanism of Action

Intercalate into DNA of microbial pathogens disrupting replication; inhibit Plasmodium falciparum haem polymerisation (antimalarial mechanism); exhibit antiviral activity by blocking viral RNA-dependent RNA polymerase in vitro.

Research Notes

Bitter KolaAfrican

Garcinia xanthones demonstrate broad in vitro antimicrobial and antiparasitic activity. Their bioavailability in human subjects has not been extensively characterised; ethnopharmacological data support traditional antimalarial and antiinfective use pending clinical validation.

Found In 1 Herb

Bitter Kola

African

3D Molecular Structure

Xanthone (oxygenated heterocyclic)

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Xanthones (Garcinia-type)

Xanthone (oxygenated heterocyclic)Bioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

Open on PubMed

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