Verbascoside (Acteoside)

In vitro / Animal

Mechanism of Action

Antioxidant; anti-inflammatory; neuroprotective (inhibits protein kinase C)

Inhibits NF-κB nuclear translocation and IκB kinase (IKK) complex activity, suppressing transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Inhibits COX-2 enzyme expression and 5-lipoxygenase activity. Scavenges superoxide radical and hydroxyl radical with potency exceeding vitamin E on a molar basis. Inhibits protein kinase C (PKC) and phospholipase A2, reducing arachidonic acid cascade activation. Protects articular cartilage by inhibiting matrix metalloproteinase-1 (MMP-1) and MMP-13 expression in chondrocytes.

Research Notes

Blue VervainWestern

Strong antioxidant activity in vitro; neuroprotective in animal models of neurodegeneration

Lemon VerbenaWestern

A randomized double-blind placebo-controlled trial (n=54) using lemon verbena extract (400 mg verbascoside daily) demonstrated significant reduction in muscle damage biomarkers (creatine kinase, lactate dehydrogenase) and improved recovery after repeated sprint exercise over a 21-day period. Multiple in vitro studies confirm potent inhibition of inflammatory mediators at nanomolar concentrations. Joint protection activity has been demonstrated in osteoarthritis cell culture models with MMP inhibition and chondrocyte protection.

Found In 2 Herbs

Blue Vervain

Western

Lemon Verbena

Western

3D Molecular Structure

Phenylpropanoid glycoside

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Verbascoside (Acteoside)

Phenylpropanoid glycosideSugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Related Compounds (Phenylpropanoid glycoside)

Eleutheroside B (Syringin)(1)Gastrodin(1)Militarine(1)Regaloside A(1)Rosarin(1)Rosavins(1)Rosin(1)

Live Research

Open on PubMed

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