Valerenic acid

Clinical trial

Mechanism of Action

GABA-A receptor β3 subunit positive allosteric modulation — distinct from benzodiazepine binding site; reduces GABA reuptake

GABA-A receptor positive allosteric modulation at the beta-3 subunit; inhibition of GABA transaminase increasing synaptic GABA levels

Research Notes

Tagara (Indian Valerian)Ayurvedic

Primary anxiolytic compound. GABA-A β3 selectivity demonstrated by Khom et al. Sedative effects enhanced by valepotriates. Clinical data largely extrapolated from V. officinalis.

ValerianWestern

Valerenic acid is the primary anxiolytic and sedative compound. Multiple RCTs demonstrate improved sleep quality with 300-600mg valerian extract. Meta-analysis supports modest but significant sleep benefits.

Found In 2 Herbs

Tagara (Indian Valerian)

Ayurvedic

Valerian

Western

3D Molecular Structure

Sesquiterpenoid carboxylic acid

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Valerenic acid

Sesquiterpenoid carboxylic acidModified terpenes with diverse biological activities

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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