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Valerenic acid
Clinical trialMechanism of Action
GABA-A receptor β3 subunit positive allosteric modulation — distinct from benzodiazepine binding site; reduces GABA reuptake
GABA-A receptor positive allosteric modulation at the beta-3 subunit; inhibition of GABA transaminase increasing synaptic GABA levels
Research Notes
Tagara (Indian Valerian)Ayurvedic
Primary anxiolytic compound. GABA-A β3 selectivity demonstrated by Khom et al. Sedative effects enhanced by valepotriates. Clinical data largely extrapolated from V. officinalis.
ValerianWestern
Valerenic acid is the primary anxiolytic and sedative compound. Multiple RCTs demonstrate improved sleep quality with 300-600mg valerian extract. Meta-analysis supports modest but significant sleep benefits.
Found In 2 Herbs
3D Molecular Structure
Sesquiterpenoid carboxylic acid
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Valerenic acid
Sesquiterpenoid carboxylic acidModified terpenes with diverse biological activities
Representative pattern: C₁₀H₁₆O
Atoms
Carbon
Oxygen
Hydrogen
Live Research
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