Umckalin (6,8-Dihydroxy-5,7-dimethoxycoumarin)

Strong

Mechanism of Action

Inhibits adhesion of bacterial pathogens (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis) to human buccal and bronchial epithelial cells, preventing colonisation without direct bactericidal activity; induces type I and type II interferon production in monocytes and macrophages, activating innate antiviral immune response; inhibits neuraminidase activity of influenza A and B viruses, limiting viral particle release; exhibits mild anticoagulant activity via inhibition of vitamin K-dependent clotting factor synthesis.

Research Notes

Pelargonium sidoidesAfrican

Umckalin is identified as the principal anti-adhesive compound in EPs® 7630. In vitro studies confirm inhibition of multiple respiratory pathogen adhesion at clinically relevant concentrations. Interferon-inducing activity has been confirmed in human peripheral blood mononuclear cell models. Its contribution to the observed clinical effects in RCTs is considered central alongside polysaccharide immunomodulation.

Found In 1 Herb

Pelargonium sidoides

African

3D Molecular Structure

Oxygenated coumarin

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Umckalin (6,8-Dihydroxy-5,7-dimethoxycoumarin)

Oxygenated coumarinBioactive phytochemical with therapeutic properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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