Triptolide

Clinical trial

Diterpene triepoxide (diterpene with three epoxide groups)

Mechanism of Action

Potent immunosuppression through T cell proliferation inhibition and NF-κB signaling blockade; TNF-α suppression

Research Notes

Triptolide is the primary bioactive in thunder god vine demonstrating remarkable anti-inflammatory and immunosuppressive effects with clinical evidence for rheumatoid arthritis and autoimmune conditions. Efficacy is significant but offset by substantial toxicity concerns and narrow therapeutic window.

Found In 1 Herb

Thunder God Vine

Western

3D Molecular Structure

Diterpene triepoxide (diterpene with three epoxide groups)

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Triptolide

Diterpene triepoxide (diterpene with three epoxide groups)Aromatic plant metabolites with anti-inflammatory properties

Representative pattern: C₁₀H₁₆O

Atoms

Carbon

Oxygen

Hydrogen

Live Research

Open on PubMed

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