Trigonelline

In vitro / Animal

Mechanism of Action

Exhibits hypoglycemic activity through enhancement of insulin sensitivity and inhibition of intestinal glucose absorption. Also shows neuroprotective effects via reduction of oxidative stress markers in neuronal tissue.

Neuroprotective and glucose-lowering properties; partially converts to nicotinic acid on roasting

Research Notes

ClavilliaSouth American

Animal studies have demonstrated trigonelline's ability to reduce fasting blood glucose and improve glucose tolerance in diabetic rat models. A 2012 study in the Journal of Ethnopharmacology showed dose-dependent hypoglycemic effects of M. jalapa root extract, attributed partly to trigonelline content.

CoffeeWestern

Moderate preclinical evidence for neuroprotective effects and glucose metabolism modulation.

Found In 2 Herbs

Clavillia

South American

Coffee

Western

3D Molecular Structure

Alkaloid (pyridine betaine)

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Trigonelline

Alkaloid (pyridine betaine)Nitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

Open on PubMed

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