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Tremella fuciformis polysaccharides (TFPS)

In vitro / Animal
Water-soluble heteropolysaccharide mixture (mannose, fucose, xylose, glucuronic acid)

Mechanism of Action

TFPS activate macrophages and dendritic cells via TLR-2 and TLR-4 receptor binding, stimulating NF-κB-mediated cytokine production (IL-2, IFN-γ, TNF-α). Enhance NK cell cytotoxicity and promote splenocyte proliferation. Distinct immunological activity from GXM — TFPS includes multiple polysaccharide fractions with different molecular weights and branching patterns that activate different arms of the innate immune system.

Research Notes

Tremella (Snow Fungus)Mushroom

Ma et al. (2010) demonstrated that TFPS enhanced macrophage phagocytosis and NO production in RAW 264.7 cells in a dose-dependent manner. Gao et al. (2017) showed TFPS improved survival and reduced tumor burden in S180-bearing mice through enhanced NK cell activity. Wen et al. (2016) found that oral TFPS supplementation enhanced mucosal IgA production in the gut of immunosuppressed mice. Human immunological data is limited to small observational studies; no large-scale RCTs on immune outcomes.

Found In 1 Herb

Tremella (Snow Fungus)

Tremella (Snow Fungus)

Mushroom

3D Molecular Structure

Water-soluble heteropolysaccharide mixture (mannose, fucose, xylose, glucuronic acid)
Drag to rotate · Click atoms to explore

Tremella fuciformis polysaccharides (TFPS)

Water-soluble heteropolysaccharide mixture (mannose, fucose, xylose, glucuronic acid)Complex carbohydrate polymers that modulate immune response

Representative pattern: (C₆H₁₀O₅)ₙ

Atoms
Carbon
Oxygen

Live Research

Open on PubMed

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