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Tremella fuciformis polysaccharides (TFPS)
In vitro / AnimalMechanism of Action
TFPS activate macrophages and dendritic cells via TLR-2 and TLR-4 receptor binding, stimulating NF-κB-mediated cytokine production (IL-2, IFN-γ, TNF-α). Enhance NK cell cytotoxicity and promote splenocyte proliferation. Distinct immunological activity from GXM — TFPS includes multiple polysaccharide fractions with different molecular weights and branching patterns that activate different arms of the innate immune system.
Research Notes
Tremella (Snow Fungus)Mushroom
Ma et al. (2010) demonstrated that TFPS enhanced macrophage phagocytosis and NO production in RAW 264.7 cells in a dose-dependent manner. Gao et al. (2017) showed TFPS improved survival and reduced tumor burden in S180-bearing mice through enhanced NK cell activity. Wen et al. (2016) found that oral TFPS supplementation enhanced mucosal IgA production in the gut of immunosuppressed mice. Human immunological data is limited to small observational studies; no large-scale RCTs on immune outcomes.
Found In 1 Herb
3D Molecular Structure
Water-soluble heteropolysaccharide mixture (mannose, fucose, xylose, glucuronic acid)
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Tremella fuciformis polysaccharides (TFPS)
Water-soluble heteropolysaccharide mixture (mannose, fucose, xylose, glucuronic acid)Complex carbohydrate polymers that modulate immune response
Representative pattern: (C₆H₁₀O₅)ₙ
Atoms
Carbon
Oxygen
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