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Tremella acidic polysaccharide (glucuronic acid-rich fraction)
In vitro / AnimalMechanism of Action
The glucuronic acid moieties provide antioxidant capacity through metal chelation (binding transition metal ions that catalyze Fenton reactions) and direct radical scavenging. In hepatocytes, glucuronic acid-rich polysaccharides upregulate superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) gene expression, enhancing endogenous antioxidant defenses. Also demonstrates prebiotic effects, promoting growth of Bifidobacterium and Lactobacillus species in the gut.
Research Notes
Tremella (Snow Fungus)Mushroom
Yang et al. (2015) showed that Tremella acidic polysaccharides protected mouse hepatocytes from CCl4-induced oxidative damage by restoring SOD and GPx activity to near-normal levels. Liu et al. (2018) demonstrated prebiotic activity of Tremella polysaccharides in human fecal fermentation models, with significant increases in short-chain fatty acid production and Bifidobacterium abundance. All evidence preclinical; human antioxidant and prebiotic studies are needed.
Found In 1 Herb
3D Molecular Structure
Acidic polysaccharide with high glucuronic acid content
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Tremella acidic polysaccharide (glucuronic acid-rich fraction)
Acidic polysaccharide with high glucuronic acid contentComplex carbohydrate polymers that modulate immune response
Representative pattern: (C₆H₁₀O₅)ₙ
Atoms
Carbon
Oxygen
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