Theobromine

Clinical trial

Mechanism of Action

Non-selective phosphodiesterase inhibitor and adenosine receptor antagonist; relaxes vascular and bronchial smooth muscle; mild positive inotropic and chronotropic cardiac effects; diuretic action through renal vasodilation

Mild CNS stimulation, bronchodilatory, and vasodilatory effects

Adenosine receptor antagonist; milder than caffeine; may promote vasodilation and mood enhancement

Research Notes

CacaoSouth American

Theobromine has been studied in multiple clinical trials demonstrating mild vasodilation, bronchodilation, and antitussive effects superior to codeine in one RCT. Cardiovascular effects include modest blood pressure reduction and improved endothelial function. Has approximately 10x less CNS stimulant potency than caffeine.

CoffeeWestern

Well-established pharmacology with clinical evidence for bronchodilatory and mild stimulant effects.

GuayusaSouth American

Well-characterized; recognized for mild psychoactive and vasodilatory effects

Found In 3 Herbs

3D Molecular Structure

Methylxanthine alkaloid

Drag to rotate · Click atoms to explore

Theobromine

Methylxanthine alkaloidNitrogen-containing compounds with potent pharmacological effects

Representative pattern: C₉H₇N₂O

Atoms

Nitrogen

Carbon

Hydrogen

Oxygen

Live Research

Open on PubMed

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