Spinosin

Moderate

Mechanism of Action

Spinosin (2"-O-beta-glucopyranosyl swertisin) modulates the serotonergic system by acting as a partial agonist at 5-HT1A receptors, which mediate anxiolytic and sleep-promoting effects. It also potentiates GABAergic transmission through allosteric interaction with GABA-A receptors at a site distinct from the benzodiazepine binding site. Spinosin has additionally been shown to reduce norepinephrine turnover in the locus coeruleus, contributing to its sedative profile.

Research Notes

Suan Zao RenTCM

A 2020 study in Phytomedicine demonstrated that spinosin at 15 mg/kg significantly reduced sleep onset latency and increased NREM sleep duration in freely moving rats, effects that were blocked by the 5-HT1A antagonist WAY-100635. In vitro binding assays confirmed affinity for 5-HT1A receptors with a Ki of approximately 8.5 uM. Multiple animal behavioral studies have confirmed dose-dependent anxiolytic activity in the elevated plus-maze and open field tests.

Found In 1 Herb

Suan Zao Ren

TCM

3D Molecular Structure

Flavonoid C-glycoside

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Spinosin

Flavonoid C-glycosidePolyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Live Research

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