Sparassol

In vitro

Mechanism of Action

Sparassol (methyl-2,4-dihydroxy-6-methylbenzoate) is an orsellinic acid derivative with antifungal and antibacterial properties. It inhibits growth of plant-pathogenic fungi (Fusarium, Rhizoctonia) by disrupting cell membrane ergosterol biosynthesis. Sparassol also demonstrates mild COX-2 inhibitory activity, contributing to anti-inflammatory effects.

Research Notes

Cauliflower MushroomMushroom

Woodward et al. (1993) first characterized sparassol as an antifungal metabolite. Subsequent screening confirmed antibacterial activity against several Gram-positive species. Anti-inflammatory activity has been demonstrated in cell-based assays. Evidence is entirely in vitro; sparassol concentration in the fruiting body is relatively low and its contribution to whole-mushroom medicinal effects is considered secondary to beta-glucan.

Found In 1 Herb

Cauliflower Mushroom

Mushroom

3D Molecular Structure

Benzoate ester (phenolic compound)

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Sparassol

Benzoate ester (phenolic compound)Simple aromatic compounds with antimicrobial properties

Representative pattern: C₇H₆O₃

Atoms

Carbon

Oxygen

Hydrogen

Live Research

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