Sodium Pyroglutamate

Preliminary

Mechanism of Action

Sodium pyroglutamate exerts anti-angiogenic effects by inhibiting von Willebrand Factor (vWF) expression in tumor-associated vasculature, disrupting platelet adhesion and endothelial cell recruitment necessary for neovascularization. It also inhibits cancer-induced immune suppression by preventing the downregulation of cytotoxic T-cell activity that tumors typically induce through immunosuppressive cytokine secretion (TGF-β, IL-10).

Research Notes

Royal Sun BlazeiMushroom

Anti-angiogenic and immune-protective activity was demonstrated in Lewis lung carcinoma mouse models, where oral sodium pyroglutamate supplementation reduced tumor vascularity and maintained cytotoxic T-cell function. The compound showed particular efficacy in pre-initiation protection paradigms. No human clinical trials have been conducted.

Found In 1 Herb

Royal Sun Blazei

Mushroom

3D Molecular Structure

Amino acid derivative

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Sodium Pyroglutamate

Amino acid derivativeBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms

Carbon

Oxygen

Nitrogen

Hydrogen

Live Research

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