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Sinigrin

In vitro / Animal
Glucosinolate

Mechanism of Action

Primary glucosinolate precursor hydrolysed to allyl isothiocyanate; responsible for pungent garlic-mustard odour and topical antimicrobial/rubefacient activity
Hydrolyzes to allyl isothiocyanate, which exerts antimicrobial and expectorant activity on respiratory mucosa
Myrosinase substrate yielding AITC upon tissue disruption; intact sinigrin exerts direct anti-inflammatory activity via NF-κB inhibition independent of AITC conversion; anti-biofilm activity against E. coli and S. aureus through surface adhesion interference; antioxidant via induction of superoxide dismutase and catalase
Antimicrobial via allyl isothiocyanate release; anti-inflammatory; immunostimulant

Research Notes

Garlic MustardWestern

Well-characterised glucosinolate found across Brassicaceae. Enzymatic hydrolysis yields allyl isothiocyanate, the primary active metabolite. Mechanism well understood.

Hedge MustardWestern

Well-documented antimicrobial and expectorant properties from allyl isothiocyanate hydrolysis product. Consistent with traditional use for respiratory infections.

HorseradishWestern

Direct anti-inflammatory and anti-biofilm activities confirmed in independent in vitro studies. Sinigrin-to-AITC conversion efficiency varies by preparation method — relevant for standardizing medicinal products. Sinigrin content of fresh horseradish root is 40–200 mg/100 g dry weight, highest in young autumn-harvested roots.

Isatis Leaf (Da Qing Ye)TCM

Sinigrin is hydrolyzed to allyl isothiocyanate providing antimicrobial activity and contributing to heat-clearing properties.

Found In 4 Herbs

Garlic Mustard

Garlic Mustard

Western
Hedge Mustard

Hedge Mustard

Western
Horseradish

Horseradish

Western
Isatis Leaf (Da Qing Ye)

Isatis Leaf (Da Qing Ye)

TCM

3D Molecular Structure

Glucosinolate
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Sinigrin

GlucosinolateBioactive phytochemical with therapeutic properties

Representative pattern: C₄H₂NO

Atoms
Carbon
Oxygen
Nitrogen
Hydrogen

Related Compounds (Glucosinolate)

Glucosinolates (glucoerucin, glucoraphanin)(1)Glucotropaeolin(1)

Live Research

Open on PubMed

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