Secoisolariciresinol diglucoside (SDG)

Clinical trial

Mechanism of Action

Metabolized by colonic bacteria to enterodiol and enterolactone, which bind estrogen receptors (primarily ER-beta) with weak agonist/antagonist activity depending on endogenous estrogen levels; inhibits aromatase and 5-alpha-reductase; antioxidant through direct radical scavenging

Research Notes

FlaxseedWestern

SDG is the primary lignan in flaxseed, present at concentrations 75-800 times higher than other dietary sources. Clinical trials demonstrate cholesterol-lowering effects, blood pressure reduction, and potential breast cancer risk reduction. The LIGNANS trial showed significant reduction in hot flash frequency in postmenopausal women. Enterolactone levels correlate inversely with breast cancer risk in epidemiological studies.

Found In 1 Herb

Flaxseed

Western

3D Molecular Structure

Lignan glycoside (phytoestrogen)

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Secoisolariciresinol diglucoside (SDG)

Lignan glycoside (phytoestrogen)Sugar-bound molecules that control drug release in the body

Representative pattern: C₁₁H₁₄O₆

Atoms

Carbon

Oxygen

Live Research

Open on PubMed

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