Rutin (rutoside)

Strong

Flavonoid glycoside (quercetin-3-O-rutinoside)

Mechanism of Action

Rutin strengthens capillary walls by inhibiting hyaluronidase and reducing capillary permeability through stabilization of endothelial gap junctions. It chelates iron ions, reducing Fenton reaction-driven hydroxyl radical formation. Rutin also inhibits platelet aggregation by blocking phosphodiesterase and reducing thromboxane A2 synthesis, and modulates VEGF signaling in vascular endothelium.

Research Notes

RueWestern

Rutin was first isolated from Ruta graveolens in 1842, giving the compound its name. Multiple clinical studies support rutin's efficacy for chronic venous insufficiency (CVI), with a Cochrane-adjacent systematic review showing significant reduction in ankle edema and heaviness symptoms. A meta-analysis of RCTs (Defined Daily Dose 500–1000 mg) for CVI showed statistically significant improvement in leg volume and symptom scores. Rutin and its semi-synthetic derivative troxerutin are approved venotonics in several European countries.

Found In 1 Herb

Rue

Western

3D Molecular Structure

Flavonoid glycoside (quercetin-3-O-rutinoside)

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Rutin (rutoside)

Flavonoid glycoside (quercetin-3-O-rutinoside)Polyphenolic antioxidants protecting cells from oxidative damage

Representative pattern: C₁₅H₁₀O₃

Atoms

Carbon

Oxygen

Live Research

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