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Rotenone
In vitro / AnimalMechanism of Action
Central nervous system depressant; potential analgesic through CNS mechanisms; MAOI-like activity; respiratory electron transport inhibition
Research Notes
Jamaican DogwoodWestern
Rotenone is the primary bioactive in Jamaican dogwood with traditional use for pain and insomnia dating centuries. Demonstrates analgesic efficacy in observational human studies, though mechanism involves CNS depression and potential neurotoxicity at elevated doses.
Found In 1 Herb
3D Molecular Structure
Isoflavonoid (pterocarpan-type)
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Rotenone
Isoflavonoid (pterocarpan-type)Polyphenolic antioxidants protecting cells from oxidative damage
Representative pattern: C₁₅H₁₀O₃
Atoms
Carbon
Oxygen
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